The Effect of the Antitumor Agent 1, l-Diphenyl-2-propynyl Cyclohexylcarbamate on the Immune Response of Mice to Sheep Red Blood Cells1

The effect of 1, l-diphenyl-2-propynyl cyclohexylcarbamate on hemagglutinin and hemolysin formation by mice in response to sheep red blood cells has been investigated. A single LDio dose of drug was administered at various times before or after immunization and the hemaggluti nin response was evaluated. With this dose the drug, de pending on time of administration in relation to primary immune exposure, will block the development of both 19 S and 7 S hemagglutinins, augment 19 S hemagglutinin formation, or selectively suppress 7 S hemagglutinin pro duction. The LO,,) dose also interferes with the secondary hemagglutinin response. Here, it is most effective when given simultaneously with antigen. The 19 S hemolysin response is suppressed by a dose of drug less than onehalf of the LDio dose. Suppression of hemolysins is most marked when the drug is given 24 hr before antigen.